| S6907 |
Rapastinel (GLYX-13) |
Rapastinel (GLYX-13, BV-102, TPPT-amide) is a partial agonist of N-methyl-D-aspartate receptor (NMDAR) that targeting a glycine site. Rapastinel has long-lasting antidepressant effects. |
Selective |
|
| S3203 |
D-Alanine |
D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) is an endogenous co-agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor. |
Selective |
|
| S3535 |
Deudextromethorphan (AVP-786) |
Deudextromethorphan (AVP-786) is an active N-methyl-D-aspartate (NMDA) receptor antagonist. |
Selective |
|
| S5032 |
Mephenesin |
Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist. |
Selective |
|
| S3624 |
Quinolinic acid |
Quinolinic Acid (pyridine-2,3-dicarboxylic acid, QUIN), a neuroactive metabolite of the kynurenine pathway, is an agonist of N-methyl-D-aspartate (NMDA) receptor.
|
Selective |
|
| S5302 |
6-Methoxy-2-naphthoic acid |
6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR. |
Selective |
|
| S5287 |
Tiletamine Hydrochloride |
Tiletamine is a lipophilc and potent vetrinary anesthetic. It is also a NMDA receptor antagonist. |
Selective |
|
| S4957 |
Linalool |
Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors. |
Selective |
|
| S2857 |
(-)-Dizocilpine (MK 801) Maleate |
(-)-Dizocilpine (MK 801, Dizocilpine, C13737) Maleate is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM. |
Selective |
NMDA receptor, Ki: 30.5 nM |
| S2876 |
(+)-Dizocilpine (MK 801) Maleate |
(+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes. |
Selective |
NMDA receptor, Kd: 37.2 nM |
| S4091 |
Ifenprodil Tartrate |
Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM. |
Selective |
NMDA Receptor, IC50: 0.3 μM |
| S0509 |
NMDAR antagonist 1 |
NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective antagonist of NMDAR. It has neuroprotective activity. |
Selective |
NMDAR, IC50: 10000 nM |
| S4023 |
Procaine HCl |
Procaine (Novocaine) is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM. |
Selective |
NMDA receptor, IC50: 0.296 mM |
| S1330 |
Felbamate |
Felbamate (Felbatol, ADD-03055,W-554) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist. |
Selective |
NMDAR, IC50: 1.8 mM |
| s4702 |
Sarcosine |
Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist. |
Selective |
|
| S4719 |
Kynurenic acid |
Kynurenic acid (Quinurenic acid, Kynurenate), a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA
receptors. |
Selective |
|
| S3653 |
Spermidine trihydrochloride |
Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA). |
Selective |
|
| S6731 |
Eliprodil (SL-820715) |
Eliprodil (SL-820715) is a non-competitive NR2B-selective NMDA antagonist with IC50 value of 1 μM and is less potent for NR2A- and NR2C-containing receptors with IC50 > 100 μM. |
Selective |
|
| S2043 |
Memantine HCl |
Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively. |
Selective |
|
| S1614 |
Riluzole (PK 26124) |
Riluzole (PK 26124, RP-54274) is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities. |
Selective |
|
| S7072 |
NMDA (N-Methyl-D-aspartic acid) |
NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4. |
Selective |
|
